Across TCGA pan-cancer cohorts, IGHD5-18 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGHD5-18 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGHD5-18 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHD5-18 expression acts as an unfavorable survival marker.

COAD are the cancer types where IGHD5-18 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.160	0.689	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: IGHD5-18 tumor-vs-normal RNA expression · all IGHD5-18 data types