Across TCGA pan-cancer cohorts, IGHD5-12 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHD5-12’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHD5-12 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHD5-12 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHD5-12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD5-12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.420	.006	3	view →
LUAD	All	All	+0.363	.007	2	view →
BRCA	Female	II,III,IV	+0.251	.010	2	view →
KIRC	All	All	+0.142	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGHD5-12 RNA expression & survival · all IGHD5-12 data types