IGHD4OR15-4A

Across TCGA patient cohorts, IGHD4OR15-4A RNA expression is significantly associated with the total protein of many other genes, with 9 significant associations in total. LGG shows the largest number of these associations.

The most reproducible IGHD4OR15-4A-associated genes across cancer lineages are GSK3-a-b, JNK_pT183_Y185, and MEK1. Each is linked with IGHD4OR15-4A in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHD4OR15-4A-to-partner and partner-to-IGHD4OR15-4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHD4OR15-4A versus GSK3-a-b in LGG, with a Pearson correlation of 0.10.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD4OR15-4A→partner) and Y-score (partner→IGHD4OR15-4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	GSK3-a-b →	+0.386	+0.049	.028	.026	3	1
LGG	JNK_pT183_Y185 →	+0.531	+0.099	.001	.025	3	1
LGG	MEK1 →	+0.568	+0.081	.017	.046	3	1
LGG	Rb_pS807_S811 →	+0.662	+0.050	.024	.025	3	1
LGG	Annexin-1 →	-0.626	-0.049	.048	.027	3	1
LGG	AR →	-0.214	-0.049	.046	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

IGHD4OR15-4A vs GSK3-a-b — LGG

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