Across TCGA pan-cancer cohorts, IGHD4-23 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IGHD4-23’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHD4-23 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHD4-23 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where IGHD4-23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD4-23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.966	<.001	6	view →
LUAD	All	All	+0.976	<.001	6	view →
STAD	Female	III,IV	+3.390	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGHD4-23 RNA expression & survival · all IGHD4-23 data types