Across TCGA patient cohorts, IGHD3-3 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,313 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD3-3-associated proteins across cancer lineages are HCLS1, IL16, and ARHGAP45. Each is linked with IGHD3-3 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHD3-3-to-partner and partner-to-IGHD3-3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD3-3→partner) and Y-score (partner→IGHD3-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCLS1 →	+0.815	+0.473	<.001	.001	3	10
GBM	IL16 →	+0.714	+0.473	<.001	.001	3	10
GBM	ARHGAP45 →	+0.662	+0.928	<.001	<.001	3	10
GBM	WAS →	+0.753	+0.473	<.001	.001	3	10
GBM	MZB1 →	+2.029	+0.566	<.001	.003	3	10
UCEC	SASH3 →	+0.501	+1.583	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,313 associations by consensus.

Exploration

IGHD3-3 survival (RNA) · tumor vs normal (RNA) · all IGHD3-3 data types