Across TCGA patient cohorts, IGHD2-15 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,216 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD2-15-associated proteins across cancer lineages are ARHGAP25, SEPTIN1, and MZB1. Each is linked with IGHD2-15 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHD2-15-to-partner and partner-to-IGHD2-15 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD2-15→partner) and Y-score (partner→IGHD2-15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP25 →	+0.478	+1.399	<.001	<.001	3	7
LSCC	SEPTIN1 →	+0.740	+1.410	<.001	<.001	3	7
UCEC	MZB1 →	+1.186	+0.928	<.001	<.001	3	6
LSCC	ARHGAP15 →	+0.499	+1.572	<.001	<.001	3	6
HNSC	STK4 →	+0.307	+1.876	.001	<.001	3	6
UCEC	ARHGAP45 →	+0.422	+0.910	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,216 associations by consensus.

Exploration

IGHD2-15 survival (RNA) · tumor vs normal (RNA) · all IGHD2-15 data types