Across TCGA pan-cancer cohorts, IGHD1-26 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHD1-26’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHD1-26 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHD1-26 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

LUAD, COAD, and READ are the cancer types where IGHD1-26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHD1-26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.835	<.001	6	view →
COAD	All	All	−0.743	.006	5	view →
READ	All	III,IV	−1.995	.010	3	view →
PAAD	Female	All	−3.905	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGHD1-26 RNA expression & survival · all IGHD1-26 data types