Across TCGA patient cohorts, IGHD RNA expression is significantly associated with the protein abundance of many other proteins, with 8,918 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHD-associated proteins across cancer lineages are MZB1, IL16, and ADA2. Each is linked with IGHD in more than 7 cancer types. Because this analysis shows association rather than direction, both IGHD-to-partner and partner-to-IGHD results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD→partner) and Y-score (partner→IGHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MZB1 →	+1.156	+1.355	<.001	<.001	3	8
BRCA	IL16 →	+0.533	+1.347	<.001	<.001	3	8
LUAD	ADA2 →	+0.445	+2.491	<.001	<.001	3	6
BRCA	CD38 →	+0.755	+1.382	<.001	<.001	3	6
BRCA	MYO1G →	+0.511	+1.549	<.001	<.001	3	6
OV	CD4 →	+0.587	+1.923	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,918 associations by consensus.

Exploration

IGHD survival (RNA) · tumor vs normal (RNA) · all IGHD data types