Across TCGA patient cohorts, IGHD protein abundance is significantly associated with the RNA expression of many other genes, with 4,638 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGHD-associated genes across cancer lineages are CHST7, IL33, and CTSG. Each is linked with IGHD in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHD-to-partner and partner-to-IGHD results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD→partner) and Y-score (partner→IGHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CHST7 →	+0.603	+0.758	.001	.004	3	4
HNSC	IL33 →	+1.298	+0.948	.002	.002	3	3
BRCA	CTSG →	+0.962	+0.646	<.001	<.001	3	3
OV	LYVE1 →	+1.126	+1.027	.003	<.001	2	4
CCRCC	DIPK2B →	+0.697	+0.802	.003	.001	3	3
CCRCC	CLDN5 →	+0.958	+0.937	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,638 associations by consensus.

Exploration

IGHD survival (RNA) · tumor vs normal (RNA) · all IGHD data types