Across TCGA patient cohorts, IGHD mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHD-associated genes across cancer lineages are MSH2, AMPK_pT172, and HER2. Each is linked with IGHD in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHD-to-partner and partner-to-IGHD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHD→partner) and Y-score (partner→IGHD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.336	-2.990	.003	.036	3	1
UCEC	AMPK_pT172 →	+0.490	+3.169	.017	.019	3	1
SKCM	HER2 →	+0.325	+3.012	.034	.018	3	1
UCEC	Ku80 →	+0.323	+2.335	.006	.020	2	1
UCEC	p62 Lck ligand →	+0.480	+3.459	.003	.005	1	1
SKCM	Smad4 →	+0.156	+3.169	.011	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

IGHD survival (RNA) · tumor vs normal (RNA) · all IGHD data types