Across TCGA patient cohorts, IGHA2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,993 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHA2-associated proteins across cancer lineages are MZB1, JCHAIN, and TXNDC5. Each is linked with IGHA2 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHA2-to-partner and partner-to-IGHA2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHA2→partner) and Y-score (partner→IGHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MZB1 →	+1.208	+1.823	<.001	<.001	3	10
LUAD	JCHAIN →	+1.197	+1.811	<.001	<.001	3	10
LSCC	TXNDC5 →	+0.594	+1.657	<.001	<.001	3	8
LSCC	CD38 →	+0.804	+1.731	<.001	<.001	3	8
GBM	IGLL5 →	+0.850	+1.516	<.001	<.001	3	8
GBM	PTPN7 →	+0.555	+1.481	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,993 associations by consensus.

Exploration

IGHA2 survival (RNA) · tumor vs normal (RNA) · all IGHA2 data types