IGHA2

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHA2 mutation is significantly associated with the RNA expression of many other genes, with 199 significant associations in total. COAD shows the largest number of these associations.

The most reproducible IGHA2-associated genes across cancer lineages are MIR548X, SNRPBP1, and RBISP1. Each is linked with IGHA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHA2-to-partner and partner-to-IGHA2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHA2→partner) and Y-score (partner→IGHA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAMIR548X →+0.465+7.471<.001.00832
COADSNRPBP1 →+0.471+4.179<.001.00232
COADRBISP1 →+0.460+4.285<.001<.00132
COADPSMB7P1 →+0.169+4.790<.001<.00132
COADBTF3P14 →+0.370+4.301<.001.00132
LUSCANAPC15P1 →+0.121+4.591<.001.00432
Each partner links to its Q-omics profile. Showing the 6 strongest of 199 associations by consensus.

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