IGFN1

Across TCGA patient cohorts, IGFN1 mutation is significantly associated with the RNA expression of many other genes, with 3,312 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFN1-associated genes across cancer lineages are ACKR3, CHAF1A, and PCAT19. Each is linked with IGFN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGFN1-to-partner and partner-to-IGFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACKR3 grouped by IGFN1-low versus IGFN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFN1→partner) and Y-score (partner→IGFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACKR3 →	-0.824	-2.793	<.001	.003	3	4
UCEC	CHAF1A →	+0.396	+1.490	.001	<.001	3	4
UCEC	PCAT19 →	-0.632	-2.070	.001	.001	3	4
SKCM	ALKBH7 →	+0.373	+1.672	.003	.006	3	4
SKCM	MTX1 →	+0.283	+2.182	.002	.001	3	3
LUAD	PPP2R2D →	+0.375	+3.505	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,312 associations by consensus.

ACKR3 by IGFN1 expression — COAD

Explore this box plot interactively →