IGFN1

Across TCGA cell cohorts, IGFN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,707 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible IGFN1-associated GO terms across cancer lineages are Actin filament depolymerization, Positive regulation of cell-substrate junction organization, and Negative regulation of post-translational protein modification. Each is linked with IGFN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGFN1-to-partner and partner-to-IGFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by IGFN1-low versus IGFN1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFN1→partner) and Y-score (partner→IGFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Actin filament depolymerization →	+0.173	+2.405	<.001	.004	3	10
LUNG_NSCLC_LUAD	Positive regulation of cell-substrate junction organization →	+0.091	+1.068	<.001	.006	3	8
SKIN	Negative regulation of post-translational protein modification →	+0.058	+1.399	<.001	.001	3	8
LUNG_NSCLC_LUAD	Synaptic vesicle recycling →	+0.064	+1.044	<.001	.007	3	7
LUNG_NSCLC_LUAD	Positive regulation of extracellular matrix disassembly →	+0.117	+1.214	.002	.005	3	6
LARGE_INTESTINE	Pigment metabolic process involved in pigmentation →	+0.122	+0.367	.003	.009	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

Actin filament depolymerization by IGFN1 expression — LIVER

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