IGFN1

Across TCGA cell cohorts, IGFN1 mutation is significantly associated with the RNA expression of many other genes, with 428 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGFN1-associated genes across cancer lineages are TCEAL5, ASIC5, and OR10A4. Each is linked with IGFN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGFN1-to-partner and partner-to-IGFN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCEAL5 grouped by IGFN1-low versus IGFN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFN1→partner) and Y-score (partner→IGFN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCEAL5 →	+0.601	+3.239	<.001	.003	3	3
LUNG_SCLC	ASIC5 →	+0.046	+2.199	<.001	.004	3	2
LIVER	OR10A4 →	+0.026	+4.392	<.001	<.001	3	2
BLOOD_Myeloma	CT47A6 →	+0.586	+4.807	<.001	.006	3	2
SKIN	GAR1 →	+0.545	+3.169	<.001	.006	3	2
SKIN	OR10AC1 →	+0.011	+1.688	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 428 associations by consensus.

TCEAL5 by IGFN1 expression — BLOOD_Leukemia

Explore this box plot interactively →