IGFLR1

Across TCGA patient cohorts, IGFLR1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFLR1-associated genes across cancer lineages are RBM15, Smad3, and Cyclin-E2. Each is linked with IGFLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFLR1-to-partner and partner-to-IGFLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBM15 grouped by IGFLR1-low versus IGFLR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFLR1→partner) and Y-score (partner→IGFLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RBM15 →	+0.419	+3.013	.023	.019	3	1
UCEC	Smad3 →	+0.231	+3.000	.008	.036	3	1
UCEC	Cyclin-E2 →	+0.252	+3.000	.009	.037	3	1
UCEC	Ku80 →	+0.417	+3.013	.002	.019	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

RBM15 by IGFLR1 expression — UCEC

Explore this box plot interactively →