IGFLR1

Across TCGA cell cohorts, IGFLR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,588 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IGFLR1-associated GO terms across cancer lineages are DNA replication checkpoint signaling, DNA strand elongation involved in DNA replication, and Mitotic DNA replication checkpoint signaling. Each is linked with IGFLR1 in more than 10 cancer types. Because this analysis shows association rather than direction, both IGFLR1-to-partner and partner-to-IGFLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by IGFLR1-low versus IGFLR1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFLR1→partner) and Y-score (partner→IGFLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNA replication checkpoint signaling →	+0.127	+0.665	.001	.001	3	11
SKIN	DNA strand elongation involved in DNA replication →	+0.142	+0.867	<.001	<.001	3	11
BONE	Mitotic DNA replication checkpoint signaling →	+0.179	+0.788	.009	.007	2	10
SKIN	Nuclear DNA replication →	+0.126	+1.093	<.001	<.001	3	9
URINARY_TRACT	Response to cell cycle checkpoint signaling →	+0.094	+1.114	.004	.001	3	9
URINARY_TRACT	Response to DNA integrity checkpoint signaling →	+0.094	+1.114	.004	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,588 associations by consensus.

DNA replication checkpoint signaling by IGFLR1 expression — SOFT_TISSUE

Explore this box plot interactively →