Across TCGA patient cohorts, IGFL2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFL2-associated genes across cancer lineages are eEF2, PEA-15_pS116, and Smac. Each is linked with IGFL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFL2-to-partner and partner-to-IGFL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFL2→partner) and Y-score (partner→IGFL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.613	+3.000	.003	.037	3	1
UCEC	PEA-15_pS116 →	+0.553	+3.000	.006	.037	3	1
UCEC	Smac →	+0.388	+3.000	.009	.037	3	1
UCEC	ERK2 →	+0.264	+3.000	.017	.037	2	1
UCEC	EGFR_pY1068 →	-0.394	-3.000	.006	.037	1	1
UCEC	Lck →	+0.308	+3.000	.008	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

IGFL2 survival (RNA) · tumor vs normal (RNA) · all IGFL2 data types