IGFBPL1

Across TCGA patient cohorts, IGFBPL1 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBPL1-associated genes across cancer lineages are RNU6-354P, OR4H12P, and GFRAL. Each is linked with IGFBPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBPL1-to-partner and partner-to-IGFBPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-354P grouped by IGFBPL1-low versus IGFBPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBPL1→partner) and Y-score (partner→IGFBPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-354P →	+0.477	+3.638	.001	.006	3	2
SKCM	OR4H12P →	+0.022	+5.488	<.001	.001	3	1
SKCM	GFRAL →	+0.043	+3.235	.006	.005	3	1
SKCM	FAM230D →	+0.176	+3.123	<.001	.007	3	1
SKCM	MIR409 →	+0.181	+4.475	<.001	.005	3	1
SKCM	RNU6-698P →	+0.152	+4.475	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

RNU6-354P by IGFBPL1 expression — UCEC

Explore this box plot interactively →