IGFBP7

Across TCGA pan-cancer cohorts, IGFBP7 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGFBP7 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IGFBP7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGFBP7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where IGFBP7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.123	0.785	.009	37	view →
HNSC	DFS	Quartile	II,III,IV	0.972	0.874	.033	6	view →
UCEC	DFS	Median	All	0.966	0.839	.016	6	view →
LSCC	OS	Quartile	II,III,IV	0.512	0.838	.014	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IGFBP7–CCRCC (OS)

Open the CCRCC breakdown →