IGFBP7

Across TCGA patient cohorts, IGFBP7 mutation is significantly associated with the RNA expression of many other genes, with 615 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP7-associated genes across cancer lineages are RNU6-1155P, MTATP6P21, and GCATP1. Each is linked with IGFBP7 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGFBP7-to-partner and partner-to-IGFBP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1155P grouped by IGFBP7-low versus IGFBP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP7→partner) and Y-score (partner→IGFBP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1155P →	+0.122	+4.475	.002	.003	3	3
UCEC	MTATP6P21 →	+0.206	+2.552	.007	.002	3	2
UCEC	GCATP1 →	+0.490	+2.627	<.001	.006	3	1
UCEC	MIR6864 →	+0.758	+2.587	<.001	<.001	3	1
UCEC	MIR6772 →	-0.819	-3.700	.009	.001	3	1
UCEC	FRG1HP →	+0.666	+2.617	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 615 associations by consensus.

RNU6-1155P by IGFBP7 expression — UCEC

Explore this box plot interactively →