IGFBP7

Across TCGA patient cohorts, IGFBP7 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP7-associated genes across cancer lineages are GATA6, eIF4E, and ERK2. Each is linked with IGFBP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP7-to-partner and partner-to-IGFBP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by IGFBP7-low versus IGFBP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP7→partner) and Y-score (partner→IGFBP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.159	-3.169	.027	.019	3	2
UCEC	eIF4E →	+0.214	+3.169	.029	.019	2	2
UCEC	ERK2 →	+0.355	+3.584	<.001	.002	3	1
UCEC	FOXO3a →	+0.106	+1.887	.025	.031	3	1
UCEC	JNK2 →	+0.370	+3.026	<.001	.018	3	1
UCEC	MEK1 →	+0.456	+3.321	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GATA6 by IGFBP7 expression — UCEC

Explore this box plot interactively →