IGFBP7

Across TCGA cell cohorts, IGFBP7 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,628 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IGFBP7-associated GO terms across cancer lineages are Protein activation cascade, Symbiont entry into host, and Symbiont entry into host cell. Each is linked with IGFBP7 in more than 13 cancer types. Because this analysis shows association rather than direction, both IGFBP7-to-partner and partner-to-IGFBP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein activation cascade grouped by IGFBP7-low versus IGFBP7-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP7→partner) and Y-score (partner→IGFBP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein activation cascade →	+0.365	+4.000	<.001	<.001	3	14
BONE	Symbiont entry into host →	+0.099	+4.283	<.001	<.001	3	14
BONE	Symbiont entry into host cell →	+0.099	+4.283	<.001	<.001	3	14
BONE	Endoderm development →	+0.157	+4.353	<.001	<.001	3	14
BONE	Viral life cycle →	+0.094	+5.071	<.001	<.001	3	14
STOMACH	Endodermal cell differentiation →	+0.212	+3.699	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,628 associations by consensus.

Protein activation cascade by IGFBP7 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →