IGFBP6

Across TCGA pan-cancer cohorts, IGFBP6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGFBP6 data layer compared with 29 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGFBP6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGFBP6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where IGFBP6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.378	0.919	.006	54	view →
HNSC	OS	Median	All	0.921	0.772	.012	12	view →
LUAD	DFS	Median	III,IV	0.595	0.886	.014	6	view →
CCRCC	DFS	Median	IV	0.749	0.253	.044	4	view →
PDAC	OS	Tertile	IV	0.916	0.231	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGFBP6–UCEC (DFS)

Open the UCEC breakdown →