IGFBP6

Across TCGA patient cohorts, IGFBP6 protein abundance is significantly associated with the RNA expression of many other genes, with 12,040 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGFBP6-associated genes across cancer lineages are THSD1, COPZ2, and CAVIN1. Each is linked with IGFBP6 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGFBP6-to-partner and partner-to-IGFBP6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGFBP6 versus THSD1 in HNSC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP6→partner) and Y-score (partner→IGFBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	THSD1 →	+1.181	+0.584	<.001	<.001	3	6
OV	COPZ2 →	+1.212	+0.488	.001	.004	2	7
COAD	CAVIN1 →	+1.476	+0.952	<.001	.001	3	5
COAD	SRPX →	+1.312	+0.986	<.001	.001	3	5
COAD	MEDAG →	+1.674	+1.367	<.001	<.001	3	5
OV	MEIS3 →	+1.021	+0.536	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,040 associations by consensus.

IGFBP6 vs THSD1 — HNSC

Explore this scatter interactively →