IGFBP6

Across TCGA patient cohorts, IGFBP6 mutation is significantly associated with the RNA expression of many other genes, with 139 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP6-associated genes across cancer lineages are RNU6-1169P, CCDC58P1, and ZYXP1. Each is linked with IGFBP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP6-to-partner and partner-to-IGFBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1169P grouped by IGFBP6-low versus IGFBP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP6→partner) and Y-score (partner→IGFBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1169P →	+0.392	+3.302	<.001	.009	3	2
SKCM	CCDC58P1 →	+0.161	+3.201	<.001	.003	3	2
BLCA	ZYXP1 →	+0.273	+7.640	<.001	.009	3	1
UCEC	IGHV3OR16-6 →	+0.845	+3.719	<.001	.006	3	1
UCEC	IGHV3OR16-13 →	+0.990	+3.896	<.001	.002	3	1
UCEC	IGHV3-79 →	+0.632	+3.823	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 139 associations by consensus.

RNU6-1169P by IGFBP6 expression — UCEC

Explore this box plot interactively →