IGFBP6

Across TCGA patient cohorts, IGFBP6 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP6-associated genes across cancer lineages are CD8+ Tem, Macrophages, and Macrophages M1. Each is linked with IGFBP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP6-to-partner and partner-to-IGFBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tem grouped by IGFBP6-low versus IGFBP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP6→partner) and Y-score (partner→IGFBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ Tem →	+0.006	+5.481	<.001	.025	3	1
UCEC	Macrophages →	+0.036	+4.072	<.001	.001	3	1
UCEC	Macrophages M1 →	+0.042	+3.065	<.001	.029	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ Tem by IGFBP6 expression — UCEC

Explore this box plot interactively →