IGFBP6

Across TCGA cell cohorts, IGFBP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,209 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IGFBP6-associated GO terms across cancer lineages are Regulation of extracellular matrix disassembly, Positive regulation of cell-substrate adhesion, and Regulation of protein maturation. Each is linked with IGFBP6 in more than 13 cancer types. Because this analysis shows association rather than direction, both IGFBP6-to-partner and partner-to-IGFBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of extracellular matrix disassembly grouped by IGFBP6-low versus IGFBP6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP6→partner) and Y-score (partner→IGFBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of extracellular matrix disassembly →	+0.203	+3.403	<.001	.001	3	14
BONE	Positive regulation of cell-substrate adhesion →	+0.133	+2.949	<.001	<.001	3	14
LIVER	Regulation of protein maturation →	+0.162	+3.527	.007	<.001	3	14
BONE	Regulation of proteolysis →	+0.108	+3.016	<.001	<.001	3	14
BONE	External encapsulating structure organization →	+0.266	+3.732	<.001	<.001	3	13
BONE	Pyrimidine-containing compound transmembrane transport →	-0.179	-3.711	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,209 associations by consensus.

Regulation of extracellular matrix disassembly by IGFBP6 expression — BONE

Explore this box plot interactively →