IGFBP6

Across TCGA cell cohorts, IGFBP6 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGFBP6-associated genes across cancer lineages are DNMT3L, GZMH, and KRT71. Each is linked with IGFBP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP6-to-partner and partner-to-IGFBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNMT3L grouped by IGFBP6-low versus IGFBP6-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP6→partner) and Y-score (partner→IGFBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNMT3L →	+0.023	+5.169	<.001	.004	3	1
STOMACH	GZMH →	+0.049	+5.285	<.001	.003	3	1
BLOOD_Leukemia	KRT71 →	+0.066	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DNMT3L by IGFBP6 expression — BONE

Explore this box plot interactively →