IGFBP5

Across TCGA pan-cancer cohorts, IGFBP5 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGFBP5’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where IGFBP5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IGFBP5 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

LSCC, HNSC, and PDAC are the cancer types where IGFBP5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGFBP5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.849	<.001	8	view →
HNSC	Male	IV	−0.723	<.001	8	view →
PDAC	Male	All	+0.853	<.001	6	view →
CCRCC	Male	III,IV	−0.545	<.001	6	view →
OV	All	All	−1.260	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGFBP5–LSCC

Open the LSCC breakdown →