IGFBP4

Across TCGA patient cohorts, IGFBP4 protein abundance is significantly associated with the RNA expression of many other genes, with 14,586 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGFBP4-associated genes across cancer lineages are TIMP1, MEDAG, and CD93. Each is linked with IGFBP4 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGFBP4-to-partner and partner-to-IGFBP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGFBP4 versus TIMP1 in GBM, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP4→partner) and Y-score (partner→IGFBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TIMP1 →	+1.246	+0.472	<.001	<.001	3	7
LUAD	MEDAG →	+1.290	+0.391	<.001	<.001	3	7
OV	CD93 →	+0.923	+0.711	<.001	.003	3	7
HNSC	FGF7 →	+1.032	+0.320	<.001	<.001	3	7
OV	DACT1 →	+1.494	+0.721	<.001	<.001	3	7
OV	IGFBP7 →	+1.170	+0.788	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,586 associations by consensus.

IGFBP4 vs TIMP1 — GBM

Explore this scatter interactively →