IGFBP4

Across TCGA patient cohorts, IGFBP4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGFBP4-associated genes across cancer lineages are eIF4E, FoxM1, and JNK_pT183_Y185. Each is linked with IGFBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP4-to-partner and partner-to-IGFBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IGFBP4-low versus IGFBP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP4→partner) and Y-score (partner→IGFBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.245	+3.169	.020	.019	3	1
UCEC	FoxM1 →	+0.269	+3.459	.038	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.265	-3.321	.001	.010	3	1
UCEC	mTOR_pS2448 →	-0.171	-2.321	.022	.035	3	1
UCEC	Notch1 →	+0.288	+3.459	<.001	.005	3	1
UCEC	p27_pT157 →	-0.067	-2.321	.022	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by IGFBP4 expression — UCEC

Explore this box plot interactively →