IGFBP4

Across TCGA cell cohorts, IGFBP4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGFBP4-associated genes across cancer lineages are MAGEB5, ETDC, and SLC5A7. Each is linked with IGFBP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGFBP4-to-partner and partner-to-IGFBP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by IGFBP4-low versus IGFBP4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGFBP4→partner) and Y-score (partner→IGFBP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	ETDC →	+0.800	+5.415	<.001	.004	3	1
BLOOD_Leukemia	SLC5A7 →	+0.006	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GALP →	+0.027	+5.201	.005	.006	3	1
BLOOD_Leukemia	FAM240A →	+0.025	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MAGEB5 by IGFBP4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →