IGFBP3

Across TCGA pan-cancer cohorts, IGFBP3 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated IGFBP3 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGFBP3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGFBP3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where IGFBP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.489	0.768	<.001	69	view →
HNSC	DFS	Quartile	All	1.000	0.839	<.001	41	view →
CCRCC	DFS	Median	II,III,IV	0.139	0.979	.001	40	view →
COAD	DFS	Median	III,IV	0.829	1.000	.027	36	view →
LSCC	OS	Tertile	III,IV	0.369	0.901	.008	32	view →
GBM	DFS	Tertile	All	0.233	0.488	.008	8	view →
PDAC	DFS	Quartile	All	0.974	0.711	.036	4	view →
UCEC	DFS	Quartile	All	0.963	0.824	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGFBP3–LUAD (DFS)

Open the LUAD breakdown →