Across TCGA patient cohorts, IGF2R mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGF2R-associated genes across cancer lineages are Caspase-7-cleavedD198, p62 Lck ligand, and 4E-BP1_pT70. Each is linked with IGF2R in more than 5 cancer types. Because this analysis shows association rather than direction, both IGF2R-to-partner and partner-to-IGF2R results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2R→partner) and Y-score (partner→IGF2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.324	+2.717	<.001	.002	3	6
LUAD	p62 Lck ligand →	+0.461	+3.169	.035	.018	3	4
COAD	4E-BP1_pT70 →	+0.105	+3.169	.018	.018	3	4
UCEC	A-Raf_pS299 →	-0.104	-1.104	<.001	.002	3	3
COAD	MEK1 →	+0.308	+3.025	<.001	<.001	3	3
UCEC	p70-S6K_pT389 →	-0.136	-1.184	.002	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

Exploration

IGF2R survival (RNA) · tumor vs normal (RNA) · all IGF2R data types