IGF2BP2

Across TCGA patient cohorts, IGF2BP2 mutation is significantly associated with the RNA expression of many other genes, with 4,341 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGF2BP2-associated genes across cancer lineages are ZWINT, CDKN3, and LIG1. Each is linked with IGF2BP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGF2BP2-to-partner and partner-to-IGF2BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by IGF2BP2-low versus IGF2BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2BP2→partner) and Y-score (partner→IGF2BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.742	+2.362	<.001	<.001	3	4
UCEC	CDKN3 →	+0.720	+1.928	<.001	<.001	3	3
UCEC	LIG1 →	+0.315	+2.161	.007	<.001	3	3
UCEC	RFC5 →	+0.464	+2.081	<.001	<.001	3	3
UCEC	PSPC1 →	+0.313	+1.869	.005	.004	3	3
UCEC	OPA3 →	+0.303	+2.523	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,341 associations by consensus.

ZWINT by IGF2BP2 expression — UCEC

Explore this box plot interactively →