IGF2BP2

Across TCGA cell cohorts, IGF2BP2 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGF2BP2-associated genes across cancer lineages are GKN2, PRRG3, and XAGE2. Each is linked with IGF2BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGF2BP2-to-partner and partner-to-IGF2BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GKN2 grouped by IGF2BP2-low versus IGF2BP2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF2BP2→partner) and Y-score (partner→IGF2BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GKN2 →	+0.140	+4.169	<.001	.002	3	2
BLOOD_Lymphoma	PRRG3 →	+0.338	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	XAGE2 →	+0.082	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	PPDPFL →	+0.777	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	TRH →	+0.047	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	OR56A1 →	+0.049	+3.523	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

GKN2 by IGF2BP2 expression — BLOOD_Lymphoma

Explore this box plot interactively →