IGF1R

Across TCGA pan-cancer cohorts, IGF1R mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGF1R data layer compared with 22 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher IGF1R mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGF1R expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

PDAC, GBM, and CCRCC are the cancer types where IGF1R mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.562	0.865	<.001	91	view →
GBM	DFS	Median	All	0.491	0.263	<.001	20	view →
CCRCC	OS	Quartile	III,IV	0.985	0.495	.002	19	view →
LUAD	OS	Quartile	II,III,IV	0.431	0.794	.012	11	view →
HNSC	DFS	Tertile	All	0.216	0.737	.046	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGF1R–PDAC (DFS)

Open the PDAC breakdown →