IGF1

Across TCGA patient cohorts, IGF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,739 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGF1-associated proteins across cancer lineages are LMOD1, TPM1, and CNN1. Each is linked with IGF1 in more than 8 cancer types. Because this analysis shows association rather than direction, both IGF1-to-partner and partner-to-IGF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGF1 versus LMOD1 in CCRCC, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1→partner) and Y-score (partner→IGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LMOD1 →	+0.980	+0.280	<.001	.003	3	9
UCEC	TPM1 →	+0.623	+0.683	<.001	.005	3	8
CCRCC	CNN1 →	+1.167	+0.295	<.001	<.001	3	8
UCEC	CNRIP1 →	+0.750	+0.706	<.001	<.001	3	8
GBM	DAB2 →	+0.788	+0.378	<.001	<.001	3	8
CCRCC	DCN →	+1.010	+0.372	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,739 associations by consensus.

IGF1 vs LMOD1 — CCRCC

Explore this scatter interactively →