IGF1

Across TCGA patient cohorts, IGF1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGF1-associated genes across cancer lineages are PCNA, S6_pS240_S244, and Cyclin-B1. Each is linked with IGF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGF1-to-partner and partner-to-IGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by IGF1-low versus IGF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1→partner) and Y-score (partner→IGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.219	+1.700	.016	.044	3	2
UCEC	S6_pS240_S244 →	+0.376	+1.700	.029	.044	3	2
UCEC	Cyclin-B1 →	+0.754	+2.222	.001	.011	3	2
UCEC	14-3-3_beta →	-0.118	-3.295	.005	.009	3	1
UCEC	EGFR_pY1068 →	-0.261	-3.169	.014	.019	3	1
UCEC	EGFR →	-0.200	-2.222	.003	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PCNA by IGF1 expression — UCEC

Explore this box plot interactively →