IGF1

Across TCGA cell cohorts, IGF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,225 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IGF1-associated GO terms across cancer lineages are Glycolate metabolic process, Negative regulation of vascular associated smooth muscle cell apoptotic process, and Bone mineralization involved in bone maturation. Each is linked with IGF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both IGF1-to-partner and partner-to-IGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycolate metabolic process grouped by IGF1-low versus IGF1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGF1→partner) and Y-score (partner→IGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Glycolate metabolic process →	-0.294	-2.751	<.001	<.001	3	13
BONE	Negative regulation of vascular associated smooth muscle cell apoptotic process →	-0.295	-2.596	<.001	<.001	3	8
BLOOD_Myeloma	Bone mineralization involved in bone maturation →	+1.822	+2.979	<.001	<.001	3	6
BONE	Regulation of T cell differentiation →	+0.050	+1.453	.002	.005	3	5
SKIN	Activation of protein kinase B activity →	-0.177	-1.181	<.001	<.001	3	5
SKIN	Regulation of potassium ion transmembrane transport →	-0.124	-1.124	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,225 associations by consensus.

Glycolate metabolic process by IGF1 expression — BONE

Explore this box plot interactively →