IGDCC4

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGDCC4 protein abundance is significantly associated with the RNA expression of many other genes, with 5,656 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGDCC4-associated genes across cancer lineages are SUDS3, DGKI, and WTAPP1. Each is linked with IGDCC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGDCC4-to-partner and partner-to-IGDCC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGDCC4 versus SUDS3 in LSCC, with a Pearson correlation of -0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGDCC4→partner) and Y-score (partner→IGDCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCSUDS3 →-0.709-0.748<.001<.00132
GBMDGKI →-0.889-0.324<.001.00932
HNSCWTAPP1 →+1.890+1.071<.001.00132
HNSCBLZF2P →+1.763+0.844<.001.00632
LSCCGOT1 →-0.652-0.614<.001<.00132
LSCCARMCX5 →-0.568-0.551<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 5,656 associations by consensus.

IGDCC4 vs SUDS3 — LSCC

Per-sample scatter of IGDCC4 vs SUDS3 in LSCC (Pearson r = -0.51).

Explore this scatter interactively →

Exploration