IGDCC4

Across TCGA patient cohorts, IGDCC4 mutation is significantly associated with the RNA expression of many other genes, with 4,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGDCC4-associated genes across cancer lineages are SDHD, TMX2, and HSBP1L1. Each is linked with IGDCC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGDCC4-to-partner and partner-to-IGDCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDHD grouped by IGDCC4-low versus IGDCC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGDCC4→partner) and Y-score (partner→IGDCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SDHD →	+0.545	+2.191	<.001	.001	3	3
UCEC	TMX2 →	+0.431	+2.446	<.001	.001	3	3
SKCM	HSBP1L1 →	+0.568	+2.231	.008	.005	3	3
LUAD	SEPTIN14P24 →	+0.147	+3.343	.007	.001	3	3
UCEC	FBXO7 →	+0.436	+1.805	<.001	<.001	3	3
SKCM	TIMM50 →	+0.454	+1.854	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,570 associations by consensus.

SDHD by IGDCC4 expression — UCEC

Explore this box plot interactively →