IGDCC4

Across TCGA patient cohorts, IGDCC4 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGDCC4-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_zeta, and FoxM1. Each is linked with IGDCC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGDCC4-to-partner and partner-to-IGDCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by IGDCC4-low versus IGDCC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGDCC4→partner) and Y-score (partner→IGDCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.877	+3.247	<.001	<.001	3	4
SKCM	14-3-3_zeta →	+0.232	+3.169	.016	.018	3	3
UCEC	FoxM1 →	+0.213	+1.523	.010	.008	3	3
UCEC	Rictor_pT1135 →	-0.079	-1.523	.016	.008	3	3
UCEC	ASNS →	+0.434	+2.906	<.001	.001	3	3
SKCM	c-Kit →	-0.651	-2.584	.031	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by IGDCC4 expression — UCEC

Explore this box plot interactively →