IGDCC3

Across TCGA patient cohorts, IGDCC3 mutation is significantly associated with the RNA expression of many other genes, with 2,555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGDCC3-associated genes across cancer lineages are CYCSP19, LINC02210-CRHR1, and CKS1BP6. Each is linked with IGDCC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGDCC3-to-partner and partner-to-IGDCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP19 grouped by IGDCC3-low versus IGDCC3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGDCC3→partner) and Y-score (partner→IGDCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CYCSP19 →	+0.272	+3.748	.007	.004	3	3
SKCM	LINC02210-CRHR1 →	+0.042	+1.931	<.001	.009	3	3
UCEC	CKS1BP6 →	+0.285	+1.723	.001	<.001	3	3
SKCM	LINC01639 →	+0.283	+1.796	<.001	.009	3	3
SKCM	CORT →	+0.374	+2.241	<.001	.005	3	3
SKCM	CDRT15P3 →	+0.023	+1.978	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,555 associations by consensus.

CYCSP19 by IGDCC3 expression — LUSC

Explore this box plot interactively →