IGDCC3

Across TCGA cell cohorts, IGDCC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,819 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible IGDCC3-associated GO terms across cancer lineages are Positive regulation of double-strand break repair via homologous recombination, Regulation of DNA-templated transcription initiation, and Regulation of DNA recombination. Each is linked with IGDCC3 in more than 11 cancer types. Because this analysis shows association rather than direction, both IGDCC3-to-partner and partner-to-IGDCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair via homologous recombination grouped by IGDCC3-low versus IGDCC3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGDCC3→partner) and Y-score (partner→IGDCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of double-strand break repair via homologous recombination →	+0.097	+1.332	<.001	<.001	3	12
STOMACH	Regulation of DNA-templated transcription initiation →	+0.063	+1.389	<.001	.003	3	10
LUNG_SCLC	Regulation of DNA recombination →	+0.070	+1.152	<.001	<.001	3	10
STOMACH	Regulation of transcription initiation by RNA polymerase II →	+0.068	+1.402	<.001	.003	3	9
OVARY	Transcription initiation at RNA polymerase II promoter →	+0.052	+0.870	<.001	.005	3	9
LARGE_INTESTINE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.042	+0.839	<.001	.002	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,819 associations by consensus.

Positive regulation of double-strand break repair via homologous recombination by IGDCC3 expression — LUNG_SCLC

Explore this box plot interactively →