IGDCC3

Across TCGA cell cohorts, IGDCC3 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IGDCC3-associated genes across cancer lineages are PRM3, TBPL2, and SH3GL2. Each is linked with IGDCC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGDCC3-to-partner and partner-to-IGDCC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM3 grouped by IGDCC3-low versus IGDCC3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGDCC3→partner) and Y-score (partner→IGDCC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRM3 →	+0.045	+4.569	<.001	.003	3	2
BLOOD_Leukemia	TBPL2 →	+0.058	+4.044	.008	.004	3	2
LARGE_INTESTINE	SH3GL2 →	+1.460	+3.252	<.001	.009	3	1
LARGE_INTESTINE	MS4A4A →	+0.169	+3.263	<.001	.001	3	1
LARGE_INTESTINE	KCNK17 →	+0.064	+2.906	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PRM3 by IGDCC3 expression — BLOOD_Leukemia

Explore this box plot interactively →