IGBP1

Across TCGA pan-cancer cohorts, IGBP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGBP1 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGBP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGBP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where IGBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.306	1.000	.013	12	view →
CCRCC	DFS	Quartile	All	0.675	0.918	.011	9	view →
PDAC	DFS	Median	All	0.553	0.348	.013	4	view →
LSCC	OS	Tertile	III,IV	0.986	0.609	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IGBP1–HNSC (DFS)

Open the HNSC breakdown →