IGBP1

Across TCGA patient cohorts, IGBP1 mutation is significantly associated with the RNA expression of many other genes, with 2,123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGBP1-associated genes across cancer lineages are TRAJ11, RNU6-1069P, and MIR4748. Each is linked with IGBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGBP1-to-partner and partner-to-IGBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ11 grouped by IGBP1-low versus IGBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGBP1→partner) and Y-score (partner→IGBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ11 →	+0.489	+1.813	<.001	.003	3	2
UCEC	RNU6-1069P →	+0.728	+1.709	<.001	.002	3	2
UCEC	MIR4748 →	+0.397	+1.788	.006	.001	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
UCEC	DGKZ →	+0.312	+3.711	.004	<.001	3	1
UCEC	LAMTOR1 →	+0.299	+1.818	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,123 associations by consensus.

TRAJ11 by IGBP1 expression — UCEC

Explore this box plot interactively →