IGBP1

Across TCGA patient cohorts, IGBP1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGBP1-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and ERK2. Each is linked with IGBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGBP1-to-partner and partner-to-IGBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by IGBP1-low versus IGBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGBP1→partner) and Y-score (partner→IGBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.082	-1.752	.029	.014	3	1
UCEC	eIF4E →	+0.174	+1.415	.028	.046	3	1
UCEC	ERK2 →	+0.144	+1.700	.047	.042	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.324	+1.415	.043	.046	3	1
UCEC	Heregulin →	-0.158	-2.906	<.001	.001	3	1
UCEC	MSH2 →	-0.259	-3.433	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

14-3-3_beta by IGBP1 expression — UCEC

Explore this box plot interactively →